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Molecular Structure and Dimeric Organization of the Notch Extracellular Domain as Revealed by Electron Microscopy

BACKGROUND: The Notch receptor links cell fate decisions of one cell to that of the immediate cellular neighbor. In humans, malfunction of Notch signaling results in diseases and congenital disorders. Structural information is essential for gaining insight into the mechanism of the receptor as well...

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Hlavní autoři: Kelly, Deborah F., Lake, Robert J., Middelkoop, Teije C., Fan, Hua-Ying, Artavanis-Tsakonas, Spyros, Walz, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866536/
https://ncbi.nlm.nih.gov/pubmed/20479883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010532
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