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Kinetic and Structural Determinants for GABA-A Receptor Potentiation by Neuroactive Steroids

Endogenous neurosteroids and synthetic neuroactive steroid analogs are among the most potent and efficacious potentiators of the mammalian GABA-A receptor. The compounds interact with one or more sites on the receptor leading to an increase in the channel open probability through a set of changes in...

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Autores principales: Akk, Gustav, Covey, Douglas F., Evers, Alex S., Mennerick, Steven, Zorumski, Charles F., Steinbach, Joe Henry
Formato: Artigo
Lenguaje:Inglês
Publicado: Bentham Science Publishers Ltd. 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866458/
https://ncbi.nlm.nih.gov/pubmed/20808543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/157015910790909458
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