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2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir.

2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]thiocarbonohydrazone (A1110U) was found to be a potent inactivator of the ribonucleotide reductases (EC 1.17.4.1) encoded by herpes simplex virus types 1 and 2 and by varicella-zoster virus and to be a weaker inactivator of human ribonucleotide reducta...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Spector, T, Harrington, J A, Morrison, R W, Lambe, C U, Nelson, D J, Averett, D R, Biron, K, Furman, P A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286619/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536930/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.3.1051
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