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Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress

Prostaglandin biosynthesis is catalyzed by two spatially and functionally distinct active sites in cyclooxygenase (COX) enzymes. Despite the crucial role of COXs in biology, molecular details regarding the function and regulation of these enzymes are incompletely defined. Reactive nitrogen species (...

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Bibliografiska uppgifter
Huvudupphovsmän: Deeb, Ruba S., Cheung, Cynthia, Nuriel, Tal, Lamon, Brian D., Upmacis, Rita K., Gross, Steven S., Hajjar, David P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866047/
https://ncbi.nlm.nih.gov/pubmed/20196542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja910578y
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