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Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress
Prostaglandin biosynthesis is catalyzed by two spatially and functionally distinct active sites in cyclooxygenase (COX) enzymes. Despite the crucial role of COXs in biology, molecular details regarding the function and regulation of these enzymes are incompletely defined. Reactive nitrogen species (...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2866047/ https://ncbi.nlm.nih.gov/pubmed/20196542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja910578y |
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