Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism

BACKGROUND: Pazopanib has shown clinical activity against multiple tumour types and is generally well tolerated. However, isolated elevations in transaminases and bilirubin have been observed. This study examined polymorphisms in molecules involved in pharmacokinetic and pharmacodynamic pathways of...

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Main Authors: Xu, C-F, Reck, B H, Xue, Z, Huang, L, Baker, K L, Chen, M, Chen, E P, Ellens, H E, Mooser, V E, Cardon, L R, Spraggs, C F, Pandite, L
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2010
Assuntos:
Molecular Diagnostics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865761/
https://ncbi.nlm.nih.gov/pubmed/20389299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605653
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