Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism

BACKGROUND: Pazopanib has shown clinical activity against multiple tumour types and is generally well tolerated. However, isolated elevations in transaminases and bilirubin have been observed. This study examined polymorphisms in molecules involved in pharmacokinetic and pharmacodynamic pathways of...

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Bibliografski detalji
Glavni autori: Xu, C-F, Reck, B H, Xue, Z, Huang, L, Baker, K L, Chen, M, Chen, E P, Ellens, H E, Mooser, V E, Cardon, L R, Spraggs, C F, Pandite, L
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Molecular Diagnostics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865761/
https://ncbi.nlm.nih.gov/pubmed/20389299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605653
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