Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism

BACKGROUND: Pazopanib has shown clinical activity against multiple tumour types and is generally well tolerated. However, isolated elevations in transaminases and bilirubin have been observed. This study examined polymorphisms in molecules involved in pharmacokinetic and pharmacodynamic pathways of...

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Hlavní autoři: Xu, C-F, Reck, B H, Xue, Z, Huang, L, Baker, K L, Chen, M, Chen, E P, Ellens, H E, Mooser, V E, Cardon, L R, Spraggs, C F, Pandite, L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865761/
https://ncbi.nlm.nih.gov/pubmed/20389299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605653
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