Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism

BACKGROUND: Pazopanib has shown clinical activity against multiple tumour types and is generally well tolerated. However, isolated elevations in transaminases and bilirubin have been observed. This study examined polymorphisms in molecules involved in pharmacokinetic and pharmacodynamic pathways of...

詳細記述

保存先:
書誌詳細
主要な著者: Xu, C-F, Reck, B H, Xue, Z, Huang, L, Baker, K L, Chen, M, Chen, E P, Ellens, H E, Mooser, V E, Cardon, L R, Spraggs, C F, Pandite, L
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2010
主題:
Molecular Diagnostics
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865761/
https://ncbi.nlm.nih.gov/pubmed/20389299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605653
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