Optimized Adeno-Associated Virus (AAV)–Protein Phosphatase-5 Helper Viruses for Efficient Liver Transduction by Single-Stranded AAV Vectors: Therapeutic Expression of Factor IX at Reduced Vector Doses

Our studies have shown that coinjection of conventional single-stranded adeno-associated virus 2 (ssAAV2) vectors carrying the enhanced green fluorescent protein (EGFP) gene with self-complementary (sc) AAV2-T cell protein tyrosine phosphatase (TC-PTP) and scAAV2-protein phosphatase-5 (PP5) vectors...

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Bibliographische Detailangaben
Hauptverfasser: Jayandharan, Giridhara R., Zhong, Li, Sack, Brandon K., Rivers, Angela E., Li, Mengxin, Li, Baozheng, Herzog, Roland W., Srivastava, Arun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2010
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865358/
https://ncbi.nlm.nih.gov/pubmed/19788390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.100
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