Pertussis Toxin Up-regulates Angiotensin Type 1 Receptors through Toll-like Receptor 4-mediated Rac Activation

Pertussis toxin (PTX) is recognized as a specific tool that uncouples receptors from G(i) and G(o) through ADP-ribosylation. During the study analyzing the effects of PTX on Ang II type 1 receptor (AT1R) function in cardiac fibroblasts, we found that PTX increases the number of AT1Rs and enhances AT...

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Bibliographic Details
Main Authors: Nishida, Motohiro, Suda, Reiko, Nagamatsu, Yuichi, Tanabe, Shihori, Onohara, Naoya, Nakaya, Michio, Kanaho, Yasunori, Shibata, Takahiro, Uchida, Koji, Sumimoto, Hideki, Sato, Yoji, Kurose, Hitoshi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865339/
https://ncbi.nlm.nih.gov/pubmed/20231290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.076232
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