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Phosphorylation of TRPC6 Channels at Thr(69) Is Required for Anti-hypertrophic Effects of Phosphodiesterase 5 Inhibition
Activation of Ca(2+) signaling induced by receptor stimulation and mechanical stress plays a critical role in the development of cardiac hypertrophy. A canonical transient receptor potential protein subfamily member, TRPC6, which is activated by diacylglycerol and mechanical stretch, works as an ups...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857061/ https://ncbi.nlm.nih.gov/pubmed/20177073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074104 |
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