TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

Structural cardiac remodeling, accompanying cytoskeletal reorganization of cardiac cells, is a major clinical outcome of diastolic heart failure. A highly local Ca(2+) influx across the plasma membrane has been suggested to code signals to induce Rho GTPase-mediated fibrosis, but it is obscure how t...

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Vydáno v:Sci Rep
Hlavní autoři: Numaga-Tomita, Takuro, Kitajima, Naoyuki, Kuroda, Takuya, Nishimura, Akiyuki, Miyano, Kei, Yasuda, Satoshi, Kuwahara, Koichiro, Sato, Yoji, Ide, Tomomi, Birnbaumer, Lutz, Sumimoto, Hideki, Mori, Yasuo, Nishida, Motohiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5171702/
https://ncbi.nlm.nih.gov/pubmed/27991560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39383
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