Rad9A Is Required for G(2) Decatenation Checkpoint and to Prevent Endoreduplication in Response to Topoisomerase II Inhibition

The Rad9A checkpoint protein interacts with and is required for proper localization of topoisomerase II-binding protein 1 (TopBP1) in response to DNA damage. Topoisomerase II (Topo II), another binding partner of TopBP1, decatenates sister chromatids that become intertwined during replication. Inhib...

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Bibliografiska uppgifter
Huvudupphovsmän: Greer Card, Deborah A., Sierant, Megan L., Davey, Scott
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
DNA and Chromosomes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865336/
https://ncbi.nlm.nih.gov/pubmed/20305300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096156
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