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Rad9A Is Required for G(2) Decatenation Checkpoint and to Prevent Endoreduplication in Response to Topoisomerase II Inhibition
The Rad9A checkpoint protein interacts with and is required for proper localization of topoisomerase II-binding protein 1 (TopBP1) in response to DNA damage. Topoisomerase II (Topo II), another binding partner of TopBP1, decatenates sister chromatids that become intertwined during replication. Inhib...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865336/ https://ncbi.nlm.nih.gov/pubmed/20305300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096156 |
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