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Hidden Function of Catalytic Domain in 6-Methylsalicylic Acid Synthase for Product Release
Functional investigation of the proposed dehydratase domain of ATX, a 6-methylsalicylic acid synthase from Aspergillus terreus, revealed that the domain is not involved in dehydration of the β-hydroxytriketide intermediate tethered on the acyl carrier protein but catalyzes thioester hydrolysis to re...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865267/ https://ncbi.nlm.nih.gov/pubmed/20304931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.107391 |
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