Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis of the Antitumor Chlorinated Polyenone Neocarzilin in “Streptomyces carzinostaticus”

Neocarzilins (NCZs) are antitumor chlorinated polyenones produced by “Streptomyces carzinostaticus” var. F-41. The gene cluster responsible for the biosynthesis of NCZs was cloned and characterized. DNA sequence analysis of a 33-kb region revealed a cluster of 14 open reading frames (ORFs), three of...

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Hauptverfasser: Otsuka, Miyuki, Ichinose, Koji, Fujii, Isao, Ebizuka, Yutaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Chemistry; Biosynthesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC514772/
https://ncbi.nlm.nih.gov/pubmed/15328113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3468-3476.2004
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