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Hidden Function of Catalytic Domain in 6-Methylsalicylic Acid Synthase for Product Release

Functional investigation of the proposed dehydratase domain of ATX, a 6-methylsalicylic acid synthase from Aspergillus terreus, revealed that the domain is not involved in dehydration of the β-hydroxytriketide intermediate tethered on the acyl carrier protein but catalyzes thioester hydrolysis to re...

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Bibliografske podrobnosti
Main Authors: Moriguchi, Tomomi, Kezuka, Yuichiro, Nonaka, Takamasa, Ebizuka, Yutaka, Fujii, Isao
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865267/
https://ncbi.nlm.nih.gov/pubmed/20304931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.107391
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