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Vincristine Attenuates N-methyl-N′-nitro-N-nitrosoguanidine-Induced Poly-(ADP) Ribose Polymerase Activity in Cardiomyocytes
The DNA-damaging agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) causes cardiomyocyte death as a result of energy loss from excessive activation of poly-(ADP) ribose polymerase-1 (PARP-1) resulting in depletion of its substrates nicotinamide adenine dinucleotide (NAD(+)) and ATP. Previously we sho...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865187/ https://ncbi.nlm.nih.gov/pubmed/20375713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e3181c87e6c |
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