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Cardiomyocyte S1P(1) Receptor–mediated Extracellular Signal–related Kinase Signaling and Desensitization
We examined the ability of sphingosine-1-phosphate (S1P) to desensitize extracellular signal–related kinase (ERK), a mitogen-activated protein kinase linked to antiapoptotic responses in the heart. In isolated adult mouse cardiomyocytes, S1P (10 nM–5 μM) induced ERK phosphorylation in a time- and do...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835551/ https://ncbi.nlm.nih.gov/pubmed/19433984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e3181a7b58a |
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