Wird geladen...

Vincristine Attenuates N-methyl-N′-nitro-N-nitrosoguanidine-Induced Poly-(ADP) Ribose Polymerase Activity in Cardiomyocytes

The DNA-damaging agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) causes cardiomyocyte death as a result of energy loss from excessive activation of poly-(ADP) ribose polymerase-1 (PARP-1) resulting in depletion of its substrates nicotinamide adenine dinucleotide (NAD(+)) and ATP. Previously we sho...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zhang, Jianqing, Chatterjee, Kanu, Alano, Conrad C., Kalinowski, Mikaila A., Honbo, Norman, Karliner, Joel S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865187/
https://ncbi.nlm.nih.gov/pubmed/20375713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e3181c87e6c
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!