Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester.
Skeletal muscle degeneration associated with mitochondrial damage was found after marked depletion of glutathione produced by administration to mice of buthionine sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase. No mitochondrial damage was found in heart. These studies sh...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1989
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286492/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2911592/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.2.471 |
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