Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.

A model for oxidative stress is described in which glutathione (GSH) synthesis is selectively blocked in newborn rats by administration of L-buthionine-(S,R)-sulfoximine (BSO). In this model, the normal endogenous physiological formation of reactive oxygen species is largely unopposed, and therefore...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Mårtensson, J, Jain, A, Stole, E, Frayer, W, Auld, P A, Meister, A
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1991
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52714/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1681551/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.20.9360
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