Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defects.

Mice treated with buthionine sulfoximine, an inhibitor of glutathione synthesis, showed striking alterations of morphology of lung type 2 cell lamellar bodies (swelling and disintegration) and mitochondria (degeneration) and of lung capillary endothelial cells (mitochondrial swelling). These effects...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Mårtensson, J, Jain, A, Frayer, W, Meister, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2748585/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.14.5296
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