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Loss of Rap1 induces telomere recombination in absence of NHEJ or a DNA damage signal
Shelterin is an essential telomeric protein complex that prevents DNA damage signaling and DNA repair at mammalian chromosome ends. Here we report on the role of the TRF2-interacting factor Rap1, a conserved shelterin subunit of unknown function. We removed Rap1 from mouse telomeres either through g...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2864730/ https://ncbi.nlm.nih.gov/pubmed/20339076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1185100 |
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