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Cross-Link Structure Affects Replication-Independent DNA Interstrand Cross-Link Repair in Mammalian Cells

DNA interstrand cross-links (ICLs) are cytotoxic products of common anti-cancer drugs and cellular metabolic processes, whose mechanism(s) of repair remain poorly understood. In this study, we show that cross-link structure affects ICL repair in non-replicating reporter plasmids that contain a mispa...

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Autors principals: Hlavin, Erica M., Smeaton, Michael B., Noronha, Anne M., Wilds, Christopher J., Miller, Paul S.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864352/
https://ncbi.nlm.nih.gov/pubmed/20373772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902169q
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