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Initiation of DNA Interstrand Cross-link Repair in Mammalian Cells
Interstrand cross-links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross-linking agents are well established in clinical use, and numerous repair pro...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911644/ https://ncbi.nlm.nih.gov/pubmed/20658650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.20559 |
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