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Initiation of DNA Interstrand Cross-link Repair in Mammalian Cells

Interstrand cross-links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross-linking agents are well established in clinical use, and numerous repair pro...

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Bibliografiske detaljer
Main Authors: Hlavin, Erica M., Smeaton, Michael B., Miller, Paul S.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911644/
https://ncbi.nlm.nih.gov/pubmed/20658650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.20559
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