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Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects
The ester bond of peptidyl-tRNA undergoes nucleophilic attack both in solution and catalyzed by the ribosome. To characterize the uncatalyzed hydrolysis reaction - a model of peptide release - the transition state structure for hydrolysis of a peptidyl-tRNA mimic was determined. Kinetic isotope effe...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2864349/ https://ncbi.nlm.nih.gov/pubmed/20359191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901458x |
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