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Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2
The X-ray structure at 2.0-Å resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory αL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the α...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2864125/ https://ncbi.nlm.nih.gov/pubmed/18084304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1347 |
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