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Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2

The X-ray structure at 2.0-Å resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory αL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the α...

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Detalhes bibliográficos
Main Authors: Malakhova, Margarita, Tereshko, Valentina, Lee, Sung-Young, Yao, Ke, Cho, Yong-Yeon, Bode, Ann, Dong, Zigang
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864125/
https://ncbi.nlm.nih.gov/pubmed/18084304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1347
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