Peripheral Site Acetylcholinesterase Inhibitors Targeting Both Inflammation and Cholinergic Dysfunction

The design and study of two classes of noncompetitive acetylcholinesterase inhibitors (AChEIs) which also function as NSAID prodrugs are reported. The most potent AChEIs disclosed contain an aromatic alkyl-aryl linker between an NSAID and a lipophilic choline mimic and they inhibit acetylcholinester...

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Detalhes bibliográficos
Main Authors: Young, Sherri, Fabio, Karine, Guillon, Christophe, Mohanta, Pramod, Halton, Timothy A., Heck, Diane E., Flowers, Robert A., Laskin, Jeffrey D., Heindel, Ned D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864113/
https://ncbi.nlm.nih.gov/pubmed/20347302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.02.102
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