Peripheral Site Acetylcholinesterase Inhibitors Targeting Both Inflammation and Cholinergic Dysfunction

The design and study of two classes of noncompetitive acetylcholinesterase inhibitors (AChEIs) which also function as NSAID prodrugs are reported. The most potent AChEIs disclosed contain an aromatic alkyl-aryl linker between an NSAID and a lipophilic choline mimic and they inhibit acetylcholinester...

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Bibliografiske detaljer
Main Authors: Young, Sherri, Fabio, Karine, Guillon, Christophe, Mohanta, Pramod, Halton, Timothy A., Heck, Diane E., Flowers, Robert A., Laskin, Jeffrey D., Heindel, Ned D.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864113/
https://ncbi.nlm.nih.gov/pubmed/20347302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.02.102
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