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Effect of the Internal Promoter on Insertional Gene Activation by Lentiviral Vectors with an Intact HIV Long Terminal Repeat
Insertional mutagenesis by viral vectors is a problem in gene therapy. We recently reported that lentiviral vectors with an intact HIV long terminal repeat (LTR) caused insertional gene activation by transcripts from the 5′ LTR splicing to an adjacent gene. Here we demonstrate that the level of tran...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863782/ https://ncbi.nlm.nih.gov/pubmed/20181689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02476-09 |
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