Virus-Specific CD8(+) T-Cell Responses Better Define HIV Disease Progression than HLA Genotype

HLA alleles B57/58, B27, and B35 have the strongest genetic associations with HIV-1 disease progression. The mechanisms of these relationships may be host control of HIV-1 infection via CD8(+) T-cell responses. We examined these immune responses in subjects from the Seattle Primary Infection Cohort...

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Autores principales: Dinges, Warren L., Richardt, Julia, Friedrich, David, Jalbert, Emilie, Liu, Yi, Stevens, Claire E., Maenza, Janine, Collier, Ann C., Geraghty, Daniel E., Smith, Jeremy, Moodie, Zoe, Mullins, James I., McElrath, M. Juliana, Horton, Helen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863751/
https://ncbi.nlm.nih.gov/pubmed/20147397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02438-09
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