Virus-Specific CD8(+) T-Cell Responses Better Define HIV Disease Progression than HLA Genotype

HLA alleles B57/58, B27, and B35 have the strongest genetic associations with HIV-1 disease progression. The mechanisms of these relationships may be host control of HIV-1 infection via CD8(+) T-cell responses. We examined these immune responses in subjects from the Seattle Primary Infection Cohort...

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Detalhes bibliográficos
Main Authors: Dinges, Warren L., Richardt, Julia, Friedrich, David, Jalbert, Emilie, Liu, Yi, Stevens, Claire E., Maenza, Janine, Collier, Ann C., Geraghty, Daniel E., Smith, Jeremy, Moodie, Zoe, Mullins, James I., McElrath, M. Juliana, Horton, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863751/
https://ncbi.nlm.nih.gov/pubmed/20147397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02438-09
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