Virus-Specific CD8(+) T-Cell Responses Better Define HIV Disease Progression than HLA Genotype

HLA alleles B57/58, B27, and B35 have the strongest genetic associations with HIV-1 disease progression. The mechanisms of these relationships may be host control of HIV-1 infection via CD8(+) T-cell responses. We examined these immune responses in subjects from the Seattle Primary Infection Cohort...

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Autors principals: Dinges, Warren L., Richardt, Julia, Friedrich, David, Jalbert, Emilie, Liu, Yi, Stevens, Claire E., Maenza, Janine, Collier, Ann C., Geraghty, Daniel E., Smith, Jeremy, Moodie, Zoe, Mullins, James I., McElrath, M. Juliana, Horton, Helen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863751/
https://ncbi.nlm.nih.gov/pubmed/20147397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02438-09
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