Evaluation of Nucleoside Hydrolase Inhibitors for Treatment of African Trypanosomiasis

In this paper, we present the biochemical and biological evaluation of N-arylmethyl-substituted iminoribitol derivatives as potential chemotherapeutic agents against trypanosomiasis. Previously, a library of 52 compounds was designed and synthesized as potent and selective inhibitors of Trypanosoma...

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Detalhes bibliográficos
Main Authors: Berg, Maya, Kohl, Linda, Van der Veken, Pieter, Joossens, Jurgen, Al-Salabi, Mohammed I., Castagna, Valeria, Giannese, Francesca, Cos, Paul, Versées, Wim, Steyaert, Jan, Grellier, Philippe, Haemers, Achiel, Degano, Massimo, Maes, Louis, de Koning, Harry P., Augustyns, Koen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863631/
https://ncbi.nlm.nih.gov/pubmed/20194690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01787-09
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