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Structural and biochemical characterization of the nucleoside hydrolase from C . elegans reveals the role of two active site cysteine residues in catalysis

Nucleoside hydrolases (NHs) catalyze the hydrolysis of the N‐glycoside bond in ribonucleosides and are found in all three domains of life. Although in parasitic protozoa a role in purine salvage has been well established, their precise function in bacteria and higher eukaryotes is still largely unkn...

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Bibliografiske detaljer
Udgivet i:Protein Sci
Main Authors: Singh, Ranjan Kumar, Steyaert, Jan, Versées, Wim
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405431/
https://ncbi.nlm.nih.gov/pubmed/28218438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3141
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