Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes

Pregnancy-associated malaria is a severe clinical syndrome associated with the sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental binding is mediated by VAR2CSA, a member of the large and diverse P. falciparum erythrocyte membrane 1 (PfEMP1) protein family. To be...

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Главные авторы: Avril, Marion, Cartwright, Megan M., Hathaway, Marianne J., Hommel, Mirja, Elliott, Salenna R., Williamson, Kathryn, Narum, David L., Duffy, Patrick E., Fried, Michal, Beeson, James G., Smith, Joseph D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2010
Предметы:
Microbial Immunity and Vaccines
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863527/
https://ncbi.nlm.nih.gov/pubmed/20194590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00410-09
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