Antibodies to a Full-Length VAR2CSA Immunogen Are Broadly Strain-Transcendent but Do Not Cross-Inhibit Different Placental-Type Parasite Isolates

The high molecular weight, multidomain VAR2CSA protein mediating adhesion of Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a pregnancy malaria vaccine. However, it has been difficult so far to generate strong and consistent adhesion blocking antibody respon...

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Bibliographic Details
Main Authors: Avril, Marion, Hathaway, Marianne J., Srivastava, Anand, Dechavanne, Sébastien, Hommel, Mirja, Beeson, James G., Smith, Joseph D., Gamain, Benoît
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034725/
https://ncbi.nlm.nih.gov/pubmed/21326877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016622
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