Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D

Bile acids are required for proper absorption of dietary lipids, including fat-soluble vitamins. Here, we show that the dietary vitamins A and D inhibit bile acid synthesis by repressing hepatic expression of the rate-limiting enzyme CYP7A1. Receptors for vitamin A and D induced expression of Fgf15,...

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Bibliografiske detaljer
Main Authors: Schmidt, Daniel R., Holmstrom, Sam R., Fon Tacer, Klementina, Bookout, Angie L., Kliewer, Steven A., Mangelsdorf, David J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863217/
https://ncbi.nlm.nih.gov/pubmed/20233723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116004
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