Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily

Transforming growth factor (TGF)-β1, -β2, and -β3 are 25-kDa homodimeric polypeptides that play crucial nonoverlapping roles in embryogenesis, tissue development, carcinogenesis, and immune regulation. Here we report the 3.0-Å resolution crystal structure of the ternary complex between human TGF-β1...

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Hlavní autoři: Radaev, Sergei, Zou, Zhongcheng, Huang, Tao, Lafer, Eileen M., Hinck, Andrew P., Sun, Peter D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863181/
https://ncbi.nlm.nih.gov/pubmed/20207738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.079921
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