The Structure of the Trimer of Human 4-1BB Ligand Is Unique among Members of the Tumor Necrosis Factor Superfamily

Binding of the 4-1BB ligand (4-1BBL) to its receptor, 4-1BB, provides the T lymphocyte with co-stimulatory signals for survival, proliferation, and differentiation. Importantly, the 4-1BB-4-1BBL pathway is a well known target for anti-cancer immunotherapy. Here we present the 2.3-Å crystal structure...

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Bibliografiska uppgifter
Huvudupphovsmän: Won, Eun-Young, Cha, Kiweon, Byun, Jung-Sue, Kim, Dong-Uk, Shin, Sumi, Ahn, Byungchan, Kim, Young Ho, Rice, Amanda J., Walz, Thomas, Kwon, Byoung S., Cho, Hyun-Soo
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838339/
https://ncbi.nlm.nih.gov/pubmed/20032458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.084442
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