Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies

Here, we demonstrate that ADAMTS9, a highly conserved versican-degrading protease, is required for correct cardiovascular development and adult homeostasis. Analysis of Adamts9(+/LacZ) heterozygous adult mice revealed anomalies in the aortic wall, valvulosinus and valve leaflets. Abnormal myocardial...

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Hlavní autoři: Kern, Christine B., Wessels, Andy, McGarity, Jessica, Dixon, Laura J., Alston, Ebony, Argraves, W. Scott, Geeting, Danielle, Nelson, Courtney M., Menick, Donald R., Ape, Suneel S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862783/
https://ncbi.nlm.nih.gov/pubmed/20096780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2010.01.005
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