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Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies
Here, we demonstrate that ADAMTS9, a highly conserved versican-degrading protease, is required for correct cardiovascular development and adult homeostasis. Analysis of Adamts9(+/LacZ) heterozygous adult mice revealed anomalies in the aortic wall, valvulosinus and valve leaflets. Abnormal myocardial...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862783/ https://ncbi.nlm.nih.gov/pubmed/20096780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2010.01.005 |
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