Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

In vivo GITR ligation has previously been shown to augment T-cell-mediated anti-tumor immunity, yet the underlying mechanisms of this activity, particularly its in vivo effects on CD4+ foxp3+ regulatory T cells (Tregs), have not been fully elucidated. In order to translate this immunotherapeutic app...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Cohen, Adam D., Schaer, David A., Liu, Cailian, Li, Yanyun, Hirschhorn-Cymmerman, Daniel, Kim, Soo Chong, Diab, Adi, Rizzuto, Gabrielle, Duan, Fei, Perales, Miguel A., Merghoub, Taha, Houghton, Alan N., Wolchok, Jedd D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862699/
https://ncbi.nlm.nih.gov/pubmed/20454651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010436
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk