Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8(+) T-Cell Responses and Tumor Immunity

Immunization of mice with plasmids encoding xenogeneic orthologues of tumor differentiation antigens can break immune ignorance and tolerance to self and induce protective tumor immunity. We sought to improve on this strategy by combining xenogeneic DNA vaccination with an agonist anti–glucocorticoi...

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Bibliographic Details
Main Authors: Cohen, Adam D., Diab, Adi, Perales, Miguel-Angel, Wolchok, Jedd D., Rizzuto, Gabrielle, Merghoub, Taha, Huggins, Deonka, Liu, Cailian, Turk, Mary Jo, Restifo, Nicholas P., Sakaguchi, Shimon, Houghton, Alan N.
Format: Artigo
Language:Inglês
Published: 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242844/
https://ncbi.nlm.nih.gov/pubmed/16651447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-05-2813
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