Optimization of a self antigen for presentation of multiple epitopes in cancer immunity

T cells recognizing self antigens expressed by cancer cells are prevalent in the immune repertoire. However, activation of these autoreactive T cells is limited by weak signals that are incapable of fully priming naive T cells, creating a state of tolerance or ignorance. Even if T cell activation oc...

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Autores principales: Guevara-Patiño, José A., Engelhorn, Manuel E., Turk, Mary Jo, Liu, Cailian, Duan, Fei, Rizzuto, Gabrielle, Cohen, Adam D., Merghoub, Taha, Wolchok, Jedd D., Houghton, Alan N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1435720/
https://ncbi.nlm.nih.gov/pubmed/16614758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25591
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