Gα(q) allosterically activates and relieves autoinhibition of p63RhoGEF

Gα(q) directly activates p63RhoGEF and closely related catalytic domains found in Trio and Kalirin, thereby linking G(q)-coupled receptors to the activation of RhoA. Although the crystal structure of Gα(q) in complex with the catalytic domains of p63RhoGEF is available, the molecular mechanism of ac...

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Bibliographic Details
Main Authors: Shankaranarayanan, Aruna, Boguth, Cassandra A., Lutz, Susanne, Vettel, Christiane, Uhlemann, Franca, Aittaleb, Mohamed, Wieland, Thomas, Tesmer, John J. G.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862694/
https://ncbi.nlm.nih.gov/pubmed/20214977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.03.006
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