The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

Phosphatidylinositol (3,4,5)-trisphosphate (PIP(3))-dependent Rac exchanger 1 (P-Rex1) catalyzes the exchange of GDP for GTP on Rac GTPases, thereby triggering changes in the actin cytoskeleton and in transcription. Its overexpression is highly correlated with the metastasis of certain cancers. P-Re...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ravala, Sandeep K., Hopkins, Jesse B., Plescia, Caroline B., Allgood, Samantha R., Kane, Madison A., Cash, Jennifer N., Stahelin, Robert V., Tesmer, John J. G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476721/
https://ncbi.nlm.nih.gov/pubmed/32661198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014534
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