The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

Phosphatidylinositol (3,4,5)-trisphosphate (PIP(3))-dependent Rac exchanger 1 (P-Rex1) catalyzes the exchange of GDP for GTP on Rac GTPases, thereby triggering changes in the actin cytoskeleton and in transcription. Its overexpression is highly correlated with the metastasis of certain cancers. P-Re...

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Pubblicato in:J Biol Chem
Autori principali: Ravala, Sandeep K., Hopkins, Jesse B., Plescia, Caroline B., Allgood, Samantha R., Kane, Madison A., Cash, Jennifer N., Stahelin, Robert V., Tesmer, John J. G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476721/
https://ncbi.nlm.nih.gov/pubmed/32661198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014534
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