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Gα(q) allosterically activates and relieves autoinhibition of p63RhoGEF
Gα(q) directly activates p63RhoGEF and closely related catalytic domains found in Trio and Kalirin, thereby linking G(q)-coupled receptors to the activation of RhoA. Although the crystal structure of Gα(q) in complex with the catalytic domains of p63RhoGEF is available, the molecular mechanism of ac...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862694/ https://ncbi.nlm.nih.gov/pubmed/20214977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.03.006 |
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