Intensive Pharmacological Immunosuppression Allows for Repetitive Liver Gene Transfer With Recombinant Adenovirus in Nonhuman Primates

Repeated administration of gene therapies is hampered by host immunity toward vectors and transgenes. Attempts to circumvent antivector immunity include pharmacological immunosuppression or alternating different vectors and vector serotypes with the same transgene. Our studies show that B-cell deple...

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Autori principali: Fontanellas, Antonio, Hervás-Stubbs, Sandra, Mauleón, Itsaso, Dubrot, Juan, Mancheño, Uxua, Collantes, María, Sampedro, Ana, Unzu, Carmen, Alfaro, Carlos, Palazón, Asis, Smerdou, Cristian, Benito, Alberto, Prieto, Jesús, Peñuelas, Iván, Melero, Ignacio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862529/
https://ncbi.nlm.nih.gov/pubmed/20087317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.312
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