Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

BACKGROUND: Adeno-associated vectors (rAAV) have been used to attain long-term liver gene expression. In humans, the cellular immune response poses a serious obstacle for transgene persistence while neutralizing humoral immunity curtails re-administration. Porphobilinogen deaminase (PBGD) haploinsuf...

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Detalhes bibliográficos
Main Authors: Unzu, Carmen, Hervás-Stubbs, Sandra, Sampedro, Ana, Mauleón, Itsaso, Mancheño, Uxua, Alfaro, Carlos, de Salamanca, Rafael Enríquez, Benito, Alberto, Beattie, Stuart G, Petry, Harald, Prieto, Jesús, Melero, Ignacio, Fontanellas, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412719/
https://ncbi.nlm.nih.gov/pubmed/22704060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-122
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